新生隱球菌(Cryptococcus neoformans)
簡介
新生隱球菌(Cryptococcus neoformans)隱球酵母科(Cryptococcaceae)革蘭陽性,酵母樣真菌,產(chǎn)莢膜(encapsulated yeast)、專性需氧胞內(nèi)真菌病原菌,產(chǎn)黑色素(melanin),培養(yǎng)時間長的菌落呈棕色,也是重要的致病因子。
臨床相關(guān)性
常存在于鳥類、主要是鴿子排泄物中。主要引起免疫抑制病人腦膜炎及腦膜腦炎(meningoencephalitis)、肺部、皮膚感染、真菌血癥;偶見引起前列腺炎、心內(nèi)膜炎、眼部感染、骨髓炎等。
參考文獻
1.Rathore SS, et al. A holistic review on Cryptococcus neoformans. Microb Pathog.2022 May;166:105521..
2.Gushiken AC, et al. Cryptococcosis. Infect Dis Clin North Am.2021 Jun;35(2):493-514.
3. Chen M, et al. The Epidemiology and Clinical
Characteristics of Fungemia in a Tertiary Hospital in Southern China:A6-Year Retrospective Study. Mycopathologia.2023 Aug;188(4):353-360.
4.McGuire CN, et al. Cryptococcus neoformans
endocarditis in an immunocompetentpatient a case report. BMC Cardiovasc Disord.2022 Dec 23;22(1):565.
5.Haider AA, et al. Intravitreal Voriconazole for the Treatment of Cryptococcus neoformans Endogenous Endophthalmitis. Ochsner J.2020 Fall;20(3):319-322.
6.Zhou HX, et al. Skeletal cryptococcosis from 1977 to2013. Front Microbiol. 2015 Jan 14;5:740.


